Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1

CONCLUSION: Pathogenic protein accumulation is a key feature of PD, and compromised V-type ATPase dysfunction might participate in PD pathogenesis. Moreover, V1G1 overexpression protects against neuronal toxicity in an MPTP-based PD mouse model, which may provide opportunities to develop novel therapeutic interventions for PD treatment.PMID:38702933 | DOI:10.1111/cns.14738

Source: CNS Neuroscience and Therapeutics - May 4, 2024 Category: Neuroscience Authors: Yunna Li Yiming Wang Liang Kou Sijia Yin Xiaosa Chi Yadi Sun Jiawei Wu Zongjie Jin Qiulu Zhou Wenkai Zou Tao Wang Yun Xia Source Type: research