Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability

CONCLUSIONS: Trem2 agonism expands atherosclerotic plaque macrophages by promoting cell survival and proliferation but improves features of plaque stability by rewiring foamy macrophage function to enhance cholesterol efflux and collagen deposition.PMID:38695172 | DOI:10.1161/ATVBAHA.124.320797

Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Michael T Patterson Yingzheng Xu Hannah Hillman Victoria Osinski Patricia R Schrank Ainsley E Kennedy Fanta Barrow Alisha Zhu Samuel Tollison Sia Shekhar Ingunn M Stromnes Ilaria Tassi Dick Wu Xavier S Revelo Bryce A Binstadt Jesse W Williams Source Type: research