Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate

CONCLUSIONS: For the first time we show that a regimen of eDMNS which does not cause bradycardia alleviates LPS-induced inflammation. These eDMNS anti-inflammatory effects require an intact vagus nerve and are not associated with corticosteroid alterations. eDMNS also decreases inflammation and improves survival in a model of polymicrobial sepsis. These findings are of interest for further studies exploring bioelectronic anti-inflammatory approaches targeting the brainstem DMN.PMID:38670240 | DOI:10.1016/j.bbi.2024.04.027

Source: Brain, Behavior, and Immunity - April 26, 2024 Category: Neurology Authors: Aidan Falvey Santhoshi P Palandira Sangeeta S Chavan Michael Brines Robert Dantzer Kevin J Tracey Valentin A Pavlov Source Type: research