Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

CONCLUSION: EC-enriched aquaporins regulate the diameter of blood vessels through an intracellular vacuole-mediated process under hyperglycemic conditions. These findings collectively suggest that aquaporins expressed in ECs hold significant promise as potential targets for gene therapy aimed at addressing vascular perfusion defects associated with diabetes.PMID:38646676 | DOI:10.1093/cvr/cvae085

Source: Cell Research - April 22, 2024 Category: Cytology Authors: Changsheng Chen Yinyin Qin Yidan Xu Xiaoning Wang Wei Lei Xiaozhong Shen Lixun Chen Linnong Wang Jie Gong Yongming Wang Shijun Hu Dong Liu Source Type: research