Association of Retinal Nerve Fiber Layer Thickness with Brain Microstructural Changes in Participants with White Matter Hyperintensities

CONCLUSIONS: We suggest neurodegeneration of peripapillary RNFL in older adults with WMH was associated with cerebral microstructural volume, impaired cerebral axonal damage, and cognitive performances. OCT metrics may provide evidence of neurodegeneration that may underpin WMH and cerebral microstructural changes in the brain.CLINICAL TRIAL REGISTRATION: This study was registered online at the China Clinical Trial Registration Center (registration number: ChiCTR-ROC-17011819).PMID:38538220 | DOI:10.31083/j.jin2303056

Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Yucong Wu Jueyue Yan Lu Xu Chunfei Xu Meiqi Zhao Zhenxiang Zhan Yi Lu Xiaozhen Liu Yungang Cao Zhao Han Source Type: research