Molecules, Vol. 29, Pages 1710: A Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein
Molecules, Vol. 29, Pages 1710: A Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein
Molecules doi: 10.3390/molecules29081710
Authors:
Zhipeng Wang
Shuang Li
Qi Li
Wenwen Wang
Meiru Liu
Shiying Yang
Li Zhang
Dezhi Yang
Guanhua Du
Yang Lu
It is well known that daidzein has various significant medicinal values and health benefits, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, cholesterol lowering, neuroprotective, cardioprotective and so on. To our disappointment, poor solubility, low permeability and inferior bioavailability seriously limit its clinical application and market development. To optimize the solubility, permeability and bioavailability of daidzein, the cocrystal of daidzein and piperazine was prepared through a scientific and reasonable design, which was thoroughly characterized by single-crystal X-ray diffraction, powder X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry and thermogravimetric analysis. Combining single-crystal X-ray diffraction analysis with theoretical calculation, detailed structural information on the cocrystal was clarified and validated. In addition, a series of evaluations on the pharmacogenetic properties of the cocrystal were investigated. The results indicated that the cocrystal of daidzein and piperazine possessed the favorable stability, increased solubility, improved permeability...
Source: Molecules - Category: Chemistry Authors: Zhipeng Wang Shuang Li Qi Li Wenwen Wang Meiru Liu Shiying Yang Li Zhang Dezhi Yang Guanhua Du Yang Lu Tags: Article Source Type: research
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