Viruses, Vol. 16, Pages 582: Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies
Viruses, Vol. 16, Pages 582: Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies
Viruses doi: 10.3390/v16040582
Authors:
Wilhelm A. J. W. Vos
Nadira Vadaq
Vasiliki Matzaraki
Twan Otten
Albert L. Groenendijk
Marc J. T. Blaauw
Louise E. van Eekeren
Kees Brinkman
Quirijn de Mast
Niels P. Riksen
Anton F. H. Stalenhoef
Jan van Lunzen
Andre J. A. M. van der Ven
Willem L. Blok
Janneke E. Stalenhoef
In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens. The 2000HIV study includes asymptomatic PLHIV (n = 1646) on long-term cART, separated into a discovery cohort with 730 INSTI and 617 NNRTI users, and a validation cohort encompassing 209 INSTI and 90 NNRTI users. Baseline plasma samples from INSTI and NNRTI users were compared using mass spectrometry-based untargeted metabolomic (n = 500) analysis. Perturbed metabolic pathways were identified using MetaboAnalyst software. Subsequently, nuclear magnetic resonance spectroscopy was used for targeted lipopr...
Source: Viruses - Category: Virology Authors: Wilhelm A. J. W. Vos Nadira Vadaq Vasiliki Matzaraki Twan Otten Albert L. Groenendijk Marc J. T. Blaauw Louise E. van Eekeren Kees Brinkman Quirijn de Mast Niels P. Riksen Anton F. H. Stalenhoef Jan van Lunzen Andre J. A. M. van der Ven Willem L. Blok Jan Tags: Article Source Type: research
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