Viruses, Vol. 16, Pages 582: Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies

Viruses, Vol. 16, Pages 582: Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies Viruses doi: 10.3390/v16040582 Authors: Wilhelm A. J. W. Vos Nadira Vadaq Vasiliki Matzaraki Twan Otten Albert L. Groenendijk Marc J. T. Blaauw Louise E. van Eekeren Kees Brinkman Quirijn de Mast Niels P. Riksen Anton F. H. Stalenhoef Jan van Lunzen Andre J. A. M. van der Ven Willem L. Blok Janneke E. Stalenhoef In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens. The 2000HIV study includes asymptomatic PLHIV (n = 1646) on long-term cART, separated into a discovery cohort with 730 INSTI and 617 NNRTI users, and a validation cohort encompassing 209 INSTI and 90 NNRTI users. Baseline plasma samples from INSTI and NNRTI users were compared using mass spectrometry-based untargeted metabolomic (n = 500) analysis. Perturbed metabolic pathways were identified using MetaboAnalyst software. Subsequently, nuclear magnetic resonance spectroscopy was used for targeted lipopr...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research