Short-term regulation of TSFM level does not alter amyloidogenesis and mitochondrial function in type-specific cells

CONCLUSIONS: Collectively, short-term regulation of TSFM level in cultured cells does not cause a significant change in proteins involved in APP processing, levels in ROS and ATP associated with mitochondrial function. Whereas our study could contribute to comprehend certain clinical features of TSFM mutations, the roles of TSFM in cardiomyopathy and cancer development might deserve further investigation.PMID:38578353 | DOI:10.1007/s11033-024-09426-4

Source: Mol Biol Cell - April 5, 2024 Category: Molecular Biology Authors: Xiao-Yun Li Gui-Feng Zhou Xiong-Yong Xie Ya-Lan Pu Xue -Chen Chen-Lu Li Jie Yang Lu Wang Guo-Jun Chen Source Type: research