Antioxidant and anticholinesterase activity of rutin in aluminum chloride-exposed Drosophila melanogaster

This study investigated the activity of rutin in mitigating Al chloride (AlCl3) toxicity inDrosophila melanogaster. Flies were divided into six groups containing fifty (50) flies each. Group A served as the control; Group B received 40  mM AlCl3; Groups C and D were co-treated with 40  mM AlCl3 + 0.5 mg/kg rutin and 40 mM AlCl3 + 1 mg/kg, respectively; Groups E and F were treated with rutin alone in doses of 0.5 mg/kg and 1 mg/kg, respectively, all through their diet. Negative geotaxis, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and acetylcholinesterase (AChE) activities were evaluated at th e end of the study. A marked decrease (P <  0.05) was noticed in survival rate, negative geotaxis, and SOD as well as a significant increase in MDA and AChE in the AlCl3-exposed flies when compared to the control. Conversely, in the groups co-treated with rutin, there was a significant attenuation of the negative effects of AlCl3. Taken together, these findings suggest that rutin protected against AlCl3, thus indicating the possible therapeutic effects of rutin against aluminum toxicity and its related disorders.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research