Mitophagy modulation for the treatment of cardiovascular diseases

CONCLUSIONS: Despite previous efforts, the molecular mechanisms underlying mitophagy activation in response to stress are not fully characterized. A comprehensive understanding of different forms of mitophagy active in the cardiovascular system is extremely important for the development of new drugs targeting this process. Human studies evaluating mitophagy abnormalities in patients at high cardiovascular risk also represent a future challenge.PMID:38530070 | DOI:10.1111/eci.14199

Source: Atherosclerosis - March 26, 2024 Category: Cardiology Authors: Maurizio Forte Luca D'Ambrosio Gabriele G Schiattarella Nadia Salerno Marco Alfonso Perrone Francesco S Loffredo Edoardo Bertero Kalliopi Pilichou Girolamo Manno Valentina Valenti Luigi Spadafora Marco Bernardi Beatrice Simeone Gianmarco Sarto Giacomo Fra Source Type: research