Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth

CONCLUSIONS: Cardiac sEVs, specifically cMSC-sEVs from post-MI hearts, carry multiple protumorigenic factors. Uptake of cMSC-sEVs by cancer cells accelerates tumor growth. Treatment with spironolactone significantly reduces accelerated tumor growth after MI. Our results provide new insight into the mechanism connecting post-MI LVD to cancer and propose a translational option to mitigate this deadly association.PMID:38487879 | DOI:10.1161/CIRCULATIONAHA.123.066911

Source: Circulation - March 15, 2024 Category: Cardiology Authors: Tal Caller Itai Rotem Olga Shaihov-Teper Daria Lendengolts Yeshai Schary Ruty Shai Efrat Glick-Saar Dan Dominissini Menachem Motiei Idan Katzir Rachela Popovtzer Merav Nahmoud Alex Boomgarden Crislyn D'Souza-Schorey Nili Naftali-Shani Jonathan Leor Source Type: research