Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study

ConclusionLevodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3  min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope.
Source: Clinical Autonomic Research - Category: Research Source Type: research