Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model

CONCLUSION: Our results demonstrate metabolic vulnerability in female prenatally MAM-exposed rats, indicating that findings from healthy animals likely provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology.PMID:38421095 | DOI:10.1111/cns.14565

Source: CNS Neuroscience and Therapeutics - February 29, 2024 Category: Neuroscience Authors: Katerina Horska Silje Skrede Jan Kucera Gabriela Kuzminova Pavel Suchy Vincenzo Micale Jana Ruda-Kucerova Source Type: research