Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of < em > Escherichia coli < /em > and < em > Klebsiella pneumoniae < /em > in Two Kenyan Facilities: A National Referral and a Level Five Hospital

CONCLUSIONS: The high proportion of ESBL-producing E. coli and K. pneumoniae isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.PMID:38384586 | PMC:PMC10881238 | DOI:10.1155/2024/7463899
Source: International Journal of Microbiology - Category: Microbiology Authors: Source Type: research