Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment

CONCLUSIONS: We identified 102 differentially expressed genes involved in the response to anti-TNF drugs in children with IBDs and validated CEACAM8, LCN2, LTF2, and PRTN3. Genes participating in defense response to Gram-negative bacterium, serine-type endopeptidase activity, and transcriptional misregulation in cancer are good candidates for anticipating the response to anti-TNF drugs in children with IBDs.PMID:38401525 | DOI:10.1016/j.biopha.2024.116299

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 24, 2024 Category: Drugs & Pharmacology Authors: Sara Salvador-Mart ín Gianluca Rubbini Perceval Vellosillo Paula Zapata-Cobo Marta Velasco Laura M Palomino Susana Clemente Oscar Segarra Ana Moreno- Álvarez Ana Fern ández-Lorenzo Bego ña Pérez-Moneo Montserrat Montraveta Cesar S ánchez Mar Tol ín Source Type: research