Disease control and late toxicity in Adaptive Dose Painting by Numbers vs. non-adaptive radiotherapy for head and neck cancer: a randomized controlled phase II trial

CONCLUSION: A-DPBN resulted in superior 1- and 2-year LC for HNC compared to S-IMRT. This supports further exploration in multicenter phase III trials. It will however be challenging to recruit a substantial patient sample for such trials as concerns have arisen on the association of late mucosal ulcers when escalating the dose in continuing smokers.PMID:38387811 | DOI:10.1016/j.ijrobp.2024.01.012

Source: Health Physics - February 22, 2024 Category: Physics Authors: Aur élie De Bruycker Wilfried De Neve Jean-Fran çois Daisne Tom Vercauteren Werner De Gersem Luiza Olteanu Dieter Berwouts St éphanie Deheneffe Indira Madani Ingeborg Goethals Fr éderic Duprez Source Type: research