Emergence of a clinical Salmonella enterica serovar 1,4,[5], 12: i:-isolate, ST3606, in China with susceptibility decrease to ceftazidime-avibactam carrying a novel blaCTX-M-261 variant and a blaNDM-5

ConclusionPlasmid-mediated horizontal transfer plays an important role inblaNDM-5 andblaCTX-M-261 dissemination, which increases the threat to public health due to the resistance to most β-lactam antibiotics. This is the first report ofblaCTX-M-261 andblaNDM-5 inS. 1,4,[5], 12: i: -. The work provides insights into the enzymatic function and demonstrates the ongoing evolution of CTX-M enzymes and confirms urgency to control resistance ofS. 1,4,[5], 12: i: -.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research