Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts: an in silico and in vitro analysis

CONCLUSION: Silymarin effectively inhibited fibroblast proliferation and downregulated genes associated with cancer progression and EMT pathway, both of which are implicated in malignant transformation. To our knowledge, this study represents the first exploration of silymarin's potential as a novel therapeutic agent in an in vitro model of OSMF.PMID:38356030 | DOI:10.1007/s11033-023-09177-8

Source: Mol Biol Cell - February 15, 2024 Category: Molecular Biology Authors: Divyambika Catakapatri Venugopal Paramesh Viswanathan Soundharya Ravindran Alan Mathew Punnoose Madhavan Yasasve Davis G Dicky John Lavanya Prabhakar Gnanasambandan Ramanathan Sathasivasubramanian Sankarapandian Vijayalakshmi Ramshankar Source Type: research