HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses

This study explored the toxicological mechanism of liver steatosis caused by PFOA/PFOS. These compounds might inhibit and down-regulate HNF4A, which is the molecular initiation events (MIE) that induces liver steatosis.PMID:38199259 | DOI:10.1016/j.cbi.2024.110867

Source: Chemico-Biological Interactions - January 10, 2024 Category: Molecular Biology Authors: Rui Li Zijing Zhang Yuxin Xuan Yulu Wang Yuyan Zhong Lingyin Zhang Jinrui Zhang Qian Chen Shuling Yu Jintao Yuan Source Type: research