Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLC γ2 but not cyclic nucleotide-dependent pathway in human

In conclusion, GK's profound impact on platelet activation, achieved through inhibiting PLCγ2-PKC cascade, culminates in the suppression of downstream signaling and, ultimately, the inhibition of platelet aggregation. These findings underscore the promising therapeutic potential of GK in the CVDs.PMID:38334198 | PMC:PMC10853947 | DOI:10.1111/jcmm.18139

Source: J Cell Mol Med - February 9, 2024 Category: Molecular Biology Authors: Chih-Wei Hsia Lan-Hsin Shu Ai-Wei Lee Oanh-Thi Tran Chih-Hao Yang Ting-Lin Yen Wei-Chieh Huang Chih-Hsuan Hsia Thanasekaran Jayakumar Kuan-Rau Chiou Joen-Rong Sheu Source Type: research