GAS5 promotes cytarabine induced myelosuppression via inhibition of hematopoietic stem cell differentiation

In conclusion, our study highlights that GAS5 inhibited the in vitro proliferation and reduced the hematopoietic colony-forming ability of cord blood-derived CD34+ cells, with the most pronounced effect observed on CFU-GEMM formation. GAS5 also enhanced the inhibitory effect of Ara-C on the in vitro hematopoietic ability of CD34+ HSCs.PMID:38290668 | DOI:10.1016/j.taap.2024.116841

Source: Toxicology and Applied Pharmacology - January 30, 2024 Category: Toxicology Authors: Yin-Xiao Du Jing Yang Han Yan Yan-Ling Liu Xiao-Ping Chen Source Type: research