Association of Cardiometabolic and Vascular Atherosclerosis Phenotypes on Non-Contrast Chest CT with Incident Heart Failure in Patients with Severe Hypercholesterolemia

Patients with severe primary hypercholesterolemia, defined as low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL, represent a high-risk group amongst patients with hyperlipidemia.1 In the statin era, patients with severe hypercholesterolemia demonstrated up to 5-fold increased risk of coronary heart disease (CHD) during their lifetime. Moreover, depending on cumulative exposure to LDL-C2, they dev eloped CHD 10-20 years earlier.1 It has been suggested that diverse genetic backgrounds and lifetime exposure to additional risk factors beyond LDL-C may introduce heterogeneity in this group3 and that coronary artery calcium (CAC) and thoracic aorta calcification (TAC) may be useful tools to predic t all-cause mortality in this population.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Original Research Source Type: research