Association of Cardiometabolic and Vascular Atherosclerosis Phenotypes on Non-Contrast Chest CT with Incident Heart Failure in Patients with Severe Hypercholesterolemia
Patients with severe primary hypercholesterolemia, defined as low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL, represent a high-risk group amongst patients with hyperlipidemia.1 In the statin era, patients with severe hypercholesterolemia demonstrated up to 5-fold increased risk of coronary heart disease (CHD) during their lifetime. Moreover, depending on cumulative exposure to LDL-C2, they dev eloped CHD 10-20 years earlier.1 It has been suggested that diverse genetic backgrounds and lifetime exposure to additional risk factors beyond LDL-C may introduce heterogeneity in this group3 and that coronary artery calcium (CAC) and thoracic aorta calcification (TAC) may be useful tools to predic t all-cause mortality in this population.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Pamela Pi ña, Daniel Lorenzatti, Francesco Castagna, Jeremy Miles, Toshiki Kuno, Andrea Scotti, Javier Arce, Ari Feinberg, Dou Huang, Jake Gilman, Ephraim Leiderman, Jonathan Daich, Paul Ippolito, Carlos A. Gongora, Aldo L Schenone, Lili Zhang, Carlos J. Tags: Original Research Source Type: research
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