Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated & quot;Inflammatory Storm & quot;

Conclusions In conclusion, our results indicated that LPS could induce depression-like behaviors and an “inflammatory storm” in vivo, activate microglia in vitro, together with a disruption of synaptic plasticity and circadian rhythm. This mechanism may be involved in the imbalanced expression of Bmal1. O ur results can help uncover a novel clock-immunological mechanism of neuroinflammation-induced depression and shed light on the development of new effective pharmacotherapies for depression
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research