Transcriptional Regulation of Treg and TH17 Differentiation

Immunology Interest Group Dr. Vijay Kuchroo is the Samuel L. Wasserstrom Professor of Neurology and the Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School. Throughout his career, Dr. Kuchroo’s primary focus has been to investigate the pathogenic and regulatory mechanisms in autoimmune diseases. His interest in regulatory T cells began during his post-doctoral fellowship in Dr. Martin Dort’s laboratory at Harvard Medical School where he analyzed antigen-specificity and requirements for the suppressive activity of regulatory T cells. As an independent investigator, Dr. Kuchroo continued to study the immunoregulatory mechanisms responsible for the prevention of organ specific autoimmunity. His laboratory identified that IL-27 was the primary inducer of IL-10-producing, regulatory Tr1 cells, which could potently suppress development of experimental autoimmune encephalomyelitis (EAE). His laboratory also identified and characterized major players of the TIM (T cell Immunoglobulin and Mucin) family of cell surface receptors: TIM-1, TIM-2, TIM-3 and TIM-4, and delineated their involvement in regulation of immune responses. Dr. Kuchroo has also made significant contributions to our understanding of the biology of CD4+ T helper cells. His laboratory was among the first to describe the molecular and cellular factors that promote differentiation and terminal maturation of TH17 cells. His extensive transcriptional profiling of TH17 cells defined dyn...
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