Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a  Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis

ConclusionA  multiparametric MRI-PWI and [18F]FET-PET model consisting of TBRmean, rCBVmean and PWI rTTP significantly outperformed the use of rTBRmean alone, which was the best single parameter approach. Secondarily, we firstly report the potential usefulness of PWI rTTP for discrimination of PD from RN in patients with glioma; however, for validation of our findings the prospective studies with larger patient samples are necessary.
Source: Clinical Neuroradiology - Category: Neurology Source Type: research