Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice

CONCLUSIONS: Our study demonstrates the effectiveness of colchicine in suppressing NLRP3 inflammasome components, thereby delaying AAA progression in the Ang II and CaCl2-induced short-term model. These findings suggest the potential of colchicine as a pharmacological treatment option for AAA.PMID:38135264 | DOI:10.1016/j.ejphar.2023.176297
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research