Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration
CONCLUSION: Our results suggest that HDAC9 plays an important role in the development and progression of IVDD. It might be required to protect NP cells against the loss of cell viability and apoptosis by inhibiting RUNX3 acetylation and expression during IVDD. Together, our findings suggest that HDAC9 may be a potential therapeutic target in IVDD.PMID:38093179 | PMC:PMC10717711 | DOI:10.1186/s11658-023-00517-x
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Ming Lei Hui Lin Deyao Shi Pan Hong Hui Song Bomansaan Herman Zhiwei Liao Cao Yang Source Type: research
More News: Adenoviruses | Back Pain | Biochemistry | Biology | Genetics | Low Back Pain | Molecular Biology | MRI Scan | Pain | Statistics | Study