Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration

CONCLUSION: Our results suggest that HDAC9 plays an important role in the development and progression of IVDD. It might be required to protect NP cells against the loss of cell viability and apoptosis by inhibiting RUNX3 acetylation and expression during IVDD. Together, our findings suggest that HDAC9 may be a potential therapeutic target in IVDD.PMID:38093179 | PMC:PMC10717711 | DOI:10.1186/s11658-023-00517-x
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Source Type: research