The gut microbiota in adults with cystic fibrosis compared to colorectal cancer

Cystic fibrosis (CF) is one of the most common, life-limiting, autosomal recessive conditions affecting Caucasian populations [1]. It is caused by biallelic mutations to the CF transmembrane conductance regulator (CFTR) gene, resulting in the absence or dysfunction of the CFTR anion channel which is expressed in epithelial cells [1]. This complex multisystem disease is associated with numerous physiological effects and complications, including lung infections, inflammation, exocrine pancreatic insufficiency (PI), CF-related diabetes (CFRD), CF-related liver disease (CFRLD) and gut dysbiosis [1,2].

Source: Journal of Cystic Fibrosis - December 15, 2023 Category: Respiratory Medicine Authors: L.R. Caley, H.M. Wood, D. Bottomley, A. Fuentes Balaguer, L. Wilkinson, J. Dyson, C. Young, H. White, S Benton, M. Brearley, P. Quirke, D.G. Peckham Tags: Original Article Source Type: research