Wireless Transcutaneous Electrical Nerve Stimulation (TENS) for Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Proof-of-Concept Randomized Clinical Trial

Chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 30 to 60% of people who receive neurotoxic chemotherapy. CIPN is associated with impaired quality of life and function and has few effective treatments. This 6-site, subject and assessor-blinded randomized clinical trial (RCT) was designed to assess 1) preliminary efficacy (ie, alpha pre-specified at .2) of a wearable, app-controlled, transcutaneous electrical nerve stimulation (TENS) device for chronic CIPN and 2) feasibility of conducting a confirmatory trial within the National Cancer Institute Community Oncology Research Program (NCORP) (NCT 04367480).

Source: The Journal of Pain - November 20, 2023 Category: Materials Science Authors: Jennifer S. Gewandter, Eva Culakova, Jenae N. Davis, Umang Gada, Joseph J. Guido, James D. Bearden, Brain Burnette, Dhaval Shah, Gary R. Morrow, Karen Mustian, Kathleen A. Sluka, Nimish Mohile Source Type: research