Lamotrigine add-on therapy for drug-resistant focal epilepsy

CONCLUSIONS: Lamotrigine as an add-on treatment for drug-resistant focal seizures is probably effective for reducing seizure frequency. Certain adverse effects (ataxia, dizziness, diplopia, and nausea) are probably more likely to occur with lamotrigine compared with placebo. There is probably little or no difference in the number of people who withdraw from treatment with lamotrigine versus placebo. The trials were of relatively short duration and provided no long-term evidence. In addition, some trials had few participants. Further trials are needed to assess the long-term effects of lamotrigine and to compare lamotrigine with other add-on drugs.PMID:38078494 | PMC:PMC10712213 | DOI:10.1002/14651858.CD001909.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research