Understand the benefits and risks of intravenous methadone for perioperative and chronic cancer pain management

AbstractIntravenous (IV) methadone is a long-acting analgesic opioid with unique properties that may be useful in the management of acute perioperative and chronic cancer pain. Several randomized clinical trials have demonstrated that intraoperative IV methadone is effective for perioperative pain and reduces the use of postoperative opioids. Limited evidence shows that IV methadone is promising for chronic cancer pain; however, further studies are required. Methadone is associated with opioid-related adverse effects, with particular safety concerns around the risk of prolonged respiratory depression and QT interval; careful dosing and monitoring is needed.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research