Brugada Syndrome: Diagnosis and Risk Stratification

Brugada Syndrome: Diagnosis and Risk Stratification Hello friends, this is the modified version of my talk at Indian Heart Rhythm Society Conference, New Delhi, 2023, on Brugada Syndrome. Hope you will enjoy this session. Initial description of Brugada syndrome in 1992 was that of syncopal episodes and/or sudden death in persons with structurally normal heart and a characteristic ECG pattern of right bundle branch block with ST segment elevation in leads V1 to V3. Sometimes individuals with a diagnostic ECG may be totally asymptomatic and may be having a family history of sudden death. Genetic nature of the disorder and mutation in sodium channel gene was described in 1998. Even though mutations in other channels have been described in Brugada syndrome, only those in SCN5A gene are considered to be definitely disease causing. Yet, SCN5A variants are identified in only about one fifth of persons with Brugada syndrome. Brugada syndrome is thought to account for about one fourth of sudden cardiac deaths in individuals with structurally normal heart. I am always happy to see this ECG of Brugada syndrome as it was sent to me by Prof. Josep Brugada way back in 2001 for the inaugural issue of IPEJ, along with his review article. Prof. Brugada’s article was the first ever article which I received for IPEJ and it gave a great boost to the debut issue of the journal [1]. ECG pattern seen in V1 and V2 with coved ST segment elevation has been called as the type 1 pattern, while the sa...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: ECG / Electrophysiology General Cardiology Source Type: blogs