COVID ‐19 and the impact on Alzheimer's disease pathology

Coronavirus disease 2019 (COVID-19) has rapidly escalated into a global pandemic. Many studies suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID-19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID-19 and AD share pathological features and risk factors. We here review the question whether COVID-19 is a risk factor for AD and how these two conditions might influence each other. The schematic shows an overview of potential mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can exacerbate molecular and cellular pathways associated with neurode generative diseases including AD. AbstractCoronavirus disease 2019 (COVID-19) has rapidly escalated into a global pandemic that primarily affects older and immunocompromised individuals due to underlying clinical conditions and suppressed immune responses. Furthermore, COVID-19 patients exhibit a spectrum of neurological symptoms, indicating that COVID-19 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID-19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD path...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research