HPV-positive clinically advanced squamous cell carcinoma of the urinary bladder (aBSCC): A comprehensive genomic profiling (CGP) study

CONCLUSIONS: HPV+ aBSCC tends to occur more often in younger patients. As reported in other HPV-associated squamous cell carcinomas, HPV+ aBSCC demonstrates significantly reduced frequencies of inactivating mutations in cell cycle regulatory genes with similar GA in MTOR and PIK3CA pathways. The implication of HPV in the pathogenesis of bladder cancer remains unknown but warrants further exploration and clinical validation.PMID:37821306 | DOI:10.1016/j.urolonc.2023.09.001

Source: Urologic Oncology - October 11, 2023 Category: Urology & Nephrology Authors: G H Ghelani M Bou Zerdan J Jacob P E Spiess R Li A Necchi P Grivas A Kamat N Danziger D Lin R Huang B Decker E S Sokol L Cheng D Pavlick J S Ross G Bratslavsky A Basnet Source Type: research