Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate

In this study we demonstrate that in contrast to adult glioma models, P-AscH- does not radiosensitize DIPG. DIPG cells were sensitive to bolus of H2O2 but have faster H2O2 removal rates than GBM models which are radiosensitized by P-AscH-. These data support the hypothesis that P-AscH- does not enhance DIPG radiosensitivity, likely due to a robust capacity to detoxify and remove hydroperoxides.PMID:37758035 | DOI:10.1667/RADE-23-00006.1

Source: Radiation Research - September 27, 2023 Category: Physics Authors: Shane R Solst Kranti A Mapuskar Claire H Graham Sarah A King Rana Rheem Kyle Current Bryan G Allen Joseph M Caster Douglas R Spitz Michelle E Howard Source Type: research