Antibacterial activity of menadione alone and in combination with oxacillin against methicillin-resistant < em > Staphylococcus aureus < /em > and its impact on biofilms

Conclusion. Menadione exhibited antibacterial and antibiofilm activity against MRSA strains, suggesting its potential as an adjunct in the treatment of S. aureus infections. The main mechanism of action involves the production of ROS, which subsequently leads to DNA damage. Additionally, the activity of menadione can be complemented by its interaction with important virulence targets.PMID:37707372 | DOI:10.1099/jmm.0.001751

Source: Journal of Medical Microbiology - September 14, 2023 Category: Microbiology Authors: Amanda Cavalcante Leit ão Thais Lima Ferreira L ívia Gurgel do Amaral Valente Sá Daniel Sampaio Rodrigues Beatriz Oliveira de Souza Amanda Dias Barbosa Lara Elloyse Almeida Moreira Jo ão Batista de Andrade Neto Vit ória Pessoa de Farias Cabral Maria Source Type: research