Preliminary PET imaging of [11C]evobrutinib in mouse models of colorectal cancer, SARS ‐CoV‐2, and lung damage: Radiosynthesis via base‐aided palladium‐NiXantphos‐mediated 11C‐carbonylation

In conclusion, [11C]evobrutinib was successfully synthesized by11C-carbonylation and based on our preliminary studies does not appear to be a promising BTK-targeted PET radiotracer in the rodent disease models studied herein.

Source: Journal of Labelled Compounds and Radiopharmaceuticals - September 11, 2023 Category: Biochemistry Authors: Amanda J. Boyle, Anton Lindberg, Junchao Tong, Dongxu Zhai, Fang Liu, Neil Vasdev Tags: RESEARCH ARTICLE Source Type: research