IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts

CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876

Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research