Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice

CONCLUSIONS: These results demonstrate that transplanted ENSCs can form effective neuromuscular connections and improve colonic motor function in a model of colonic dysmotility, and additionally reveal that multiple sites of cell delivery led to an improved response, paving the way for optimized clinical trial design.PMID:37667277 | DOI:10.1186/s13287-023-03469-3

Source: Cell Research - September 4, 2023 Category: Cytology Authors: Ryo Hotta Ahmed Rahman Sukhada Bhave Rhian Stavely Weikang Pan Shriya Srinivasan Geoffrey de Couto Luis Rodriguez-Borlado Richard Myers Alan J Burns Allan M Goldstein Source Type: research