Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals

This study lays the groundwork for identifying broad-acting, host-targeted therapies to reduce betacoronavirus replication that can be rapidly repurposed during future outbreaks and epidemics. The proteomics, phosphoproteomics, and MIB-MS datasets generated in this study are available in the Proteomics Identification Database (PRIDE) repository under project identifiers PXD040897 and PXD040901.PMID:37634194 | DOI:10.1021/acs.jproteome.3c00182

Source: Cell Research - August 27, 2023 Category: Cytology Authors: Ethan J Fritch Angie L Mordant Thomas S K Gilbert Carrow I Wells Xuan Yang Natalie K Barker Emily A Madden Kenneth H Dinnon Yixuan J Hou Longping V Tse Izabella N Castillo Amy C Sims Nathaniel J Moorman Premkumar Lakshmanane Timothy M Willson Laura E Herr Source Type: research