Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways

CONCLUSIONS: Differential patterns of methylation were identified between controls and CRS, CRSwNP, and CRSsNP. Epigenetic, environmentally-induced changes related to novel, inflammatory, immunologic, and remodeling pathways appear to affect epithelial integrity, cell proliferation, homeostasis, vascular permeability, and other yet uncharacterized pathways and genes.PMID:37584357 | DOI:10.1177/19458924231193526

Source: American Journal of Rhinology and Allergy - August 16, 2023 Category: ENT & OMF Authors: Tripti Brar Saurabh Baheti Michael J Marino Hirohito Kita Devyani Lal Source Type: research