Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome

CONCLUSIONS: miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.PMID:37620736 | DOI:10.1007/s11033-023-08604-0

Source: Molecular Biology Reports - August 24, 2023 Category: Molecular Biology Authors: Heba S Omar Osama Ahmed Ibrahim Maha Gomaa Sayed Eman Mohammed Faruk Hanan Fouad Miriam Safwat Source Type: research