A study of genetic variants, genetic risk score and DNA methylation of PNPLA3 and TM6SF2 in alcohol liver cirrhosis

ConclusionWe found that a genetic risk score based on SNPs in thePNPLA3 andTM6SF2 genes was significantly associated with cirrhosis in patients with AUD, suggesting a potential utility in identifying patients at risk and providing pre-emptive interventions. These may include interventions that aim to alter DNA methylation, which may be one of the mechanisms through which elevated genetic risk may influence the  development of cirrhosis.Graphical abstract
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research