Evaluation of Chromosome 1p/19q deletion by Fluorescence in Situ Hybridization (FISH) as prognostic factors in malignant glioma patients on treatment with alkylating chemotherapy

Glioma, the most frequent brain tumor occurs at a frequency of 1.6% as per Global Cancer Statistics, male: female ratio of age-standardized risk as 3.9:3.1 [1]. Glioma displays a widespread heterogeneity at morphological site, genetic model and response to chemo-radiotherapy. Glioblastoma (GBM) is mainly the most frequent among the different types of malignant glioma with aggressive nature [2,3]. In addition to epigenetic alterations like mutations in IDH and MGMT gene hypermethylation respectively, chromosomal variations mostly in chromosome 1p/19q deletion have been detected in malignant gliomas [4].

Source: Cancer Genetics and Cytogenetics - August 10, 2023 Category: Genetics & Stem Cells Authors: Arshad A. Pandith, Wani Zahoor, Usma Manzoor, Syed Nisar, Faisal R. Guru, Niyaz A. Naikoo, Qurat ul Aein, Shahid M. Baba, Abdul R Bhat, Farooq Ganai, Parveen Shah Source Type: research