Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver

Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercaloric); isocaloric and hypocaloric (energy reduction of 20%). Fasting blood glucose levels and total fat in the liver were higher in all HFLC diet rats. Oral glucose tolerance was impaired in isocaloric and hypercaloric groups, although insulin sensitivity wasn´t altered. HFLC diet also caused marked liver metabolic alterations: higher gluconeogenesis rate from lactate and a reduced capacity to metabolize alanine, the latter effect being more intense in the hypocaloric condition. Thus, even when HFLC diets are used for weight loss, our data imply that they can potentially cause harmful consequences for the liver.PMID:37523769 | DOI:10.1139/cjpp-2023-0071

Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research