Novel therapeutic approaches in the management of chronic kidney disease: a narrative review

Postgrad Med. 2023 Jul 4. doi: 10.1080/00325481.2023.2233492. Online ahead of print.ABSTRACTChronic kidney disease (CKD) remains a pathologic entity with constantly rising incidence and high rates of morbidity and mortality, which are associated with serious cardiovascular complications. Moreover, the incidence of end-stage renal disease tends to increase. The epidemiological trends of CKD warrant the development of novel therapeutic approaches aiming to prevent its development or retard its progression through the control of major risk factors: type 2 diabetes mellitus, arterial hypertension, and dyslipidemia. Contemporary therapeutics such as sodium-glucose cotransporter-2 inhibitors and second-generation mineralocorticoid receptor antagonists are utilized in this direction. Additionally, experimental and clinical studies present novel drug categories that could be employed in managing CKD, such as aldosterone synthesis inhibitors or activators guanylate cyclase, while the role of melatonin should be further tested in the clinical setting. Finally, in this patient population, the use of hypolipidemic agents may provide incremental benefits.PMID:37401536 | DOI:10.1080/00325481.2023.2233492

Source: Postgraduate Medicine - July 4, 2023 Category: Internal Medicine Authors: Panagiotis Theofilis Aikaterini Vordoni Rigas G Kalaitzidis Source Type: research