Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes

Chest. 2023 Jun 17:S0012-3692(23)00794-8. doi: 10.1016/j.chest.2023.05.031. Online ahead of print.ABSTRACTBACKGROUND: The prospective associations of preserved ratio impaired spirometry (PRISm) with new-onset macrovascular and microvascular complications and mortality among individuals with type 2 diabetes (T2D) and whether PRISm enhances the prediction ability of an established office-based risk score remains to be elucidated.RESEARCH QUESTION: Can PRISm be used as a predictor of poor prognosis in individuals with T2D?STUDY DESIGN AND METHODS: We included 20,047 study participants with T2D and complete data on spirometry at recruitment from the UK Biobank cohort. Multivariable Cox proportional hazards models were used to assess the associations of baseline PRISm (FEV1 to FVC ratio, ≥ 0.70; FEV1, < 80% predicted) with subsequent risks of incident stroke (any type), ischemic stroke (IS), myocardial infarction (MI), unstable angina, coronary heart disease (CHD), diabetic retinopathy (DR), diabetic kidney disease (DKD), all-cause mortality, cardiovascular mortality, and respiratory mortality.RESULTS: For this cohort analysis, 4,521 patients (22.55% of participants with T2D) showed comorbid PRISm at baseline. Over a median follow-up of 11.52 to 11.87 years, patients with T2D with PRISm at baseline showed higher risks than those with normal spirometry findings of various T2D complications developing and mortality; the adjusted hazard ratios for PRISm were 1.413 (95% CI, 1.187...
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research