Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway

In conclusion, our findings demonstrate for the first time the direct toxic effects of CFZ in endothelial cells and the associated signaling changes. Canagliflozin abrogated the apoptotic effects of CFZ in endothelial cells in an AMPK-dependent mechanism, without interfering with its cytotoxicity in cancer cells.PMID:37247463 | DOI:10.1016/j.biopha.2023.114907

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2023 Category: Drugs & Pharmacology Authors: Mohamed S Dabour Ibrahim Y Abdelgawad Marianne K O Grant Engie S El-Sawaf Beshay N Zordoky Source Type: research