Molecules, Vol. 28, Pages 4048: Exploitation of Sugarcane Bagasse and Environmentally Sustainable Production, Purification, Characterization, and Application of Lovastatin by Aspergillus terreus AUMC 15760 under Solid-State Conditions
Molecules, Vol. 28, Pages 4048: Exploitation of Sugarcane Bagasse and Environmentally Sustainable Production, Purification, Characterization, and Application of Lovastatin by Aspergillus terreus AUMC 15760 under Solid-State Conditions
Molecules doi: 10.3390/molecules28104048
Authors:
Ahmed M. A. A. Ramadan
Reda M. Shehata
Hussein H. EL-Sheikh
Fuad Ameen
Steven L. Stephenson
Sabry A. H. Zidan
Osama A. M. Al-Bedak
Using the internal transcribed spacer (ITS) region for identification, three strains of Aspergillus terreus were identified and designated AUMC 15760, AUMC 15762, and AUMC 15763 for the Assiut University Mycological Centre culture collection. The ability of the three strains to manufacture lovastatin in solid-state fermentation (SSF) using wheat bran was assessed using gas chromatography-mass spectroscopy (GC-MS). The most potent strain was strain AUMC 15760, which was chosen to ferment nine types of lignocellulosic waste (barley bran, bean hay, date palm leaves, flax seeds, orange peels, rice straw, soy bean, sugarcane bagasse, and wheat bran), with sugarcane bagasse turning out to be the best substrate. After 10 days at pH 6.0 at 25 °C using sodium nitrate as the nitrogen source and a moisture content of 70%, the lovastatin output reached its maximum quantity (18.2 mg/g substrate). The medication was produced in lactone form as a white powder in its purest form using column chromatography. In-depth spectroscopy examination, including ...
Source: Molecules - Category: Chemistry Authors: Ahmed M. A. A. Ramadan Reda M. Shehata Hussein H. EL-Sheikh Fuad Ameen Steven L. Stephenson Sabry A. H. Zidan Osama A. M. Al-Bedak Tags: Article Source Type: research
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