Delayed cortical thinning in children and adolescents with prenatal alcohol exposure

CONCLUSIONS: Regional differences were seen longitudinally in the trajectory and timing of CT change in children with PAE, suggesting delayed cortical maturation and an atypical pattern of development compared with typically developing individuals. In addition, exploratory correlation analyses of SPC and EF performance suggest the presence of atypical brain-behavior relationships in PAE. The findings highlight the potential role of altered developmental timing of cortical maturation in contributing to long-term functional impairment in PAE.PMID:37132064 | DOI:10.1111/acer.15096

Source: Alcoholism, Clinical and Experimental Research - May 3, 2023 Category: Addiction Authors: Blake A Gimbel Donovan J Roediger Abigail M Ernst Mary E Anthony Erik de Water Bryon A Mueller Madeline N Rockhold Moss J Schumacher Sarah N Mattson Kenneth L Jones Kelvin O Lim Jeffrey R Wozniak Source Type: research